Obesity

Association of weight loss with cardiovascular or all-cause mortality in patients with heart failure: A meta-analysis

Int J Obes (Lond)Published Systematic review and meta-analysis of post hoc analyses of RCTs and observational studies

Pooled result · All-cause mortalityResult — go to the resultPooled adjusted hazard ratio 1.75 95% CI 1.43–2.14

Authors' conclusion

Weight loss is associated with an increased risk of cardiovascular and all-cause mortality in patients with HF. Assessing weight changes can provide prognostic information for patients with HF.

Study context

Population
Patients with heart failure (HF); PubMed and Embase searched up to May 7, 202312 articles
Participants
26,164 patients13 studies
Comparison
Weight loss vs stable weight
Outcome
All-cause mortality

Pooled result

As reported in the abstract

Pooled adjusted hazard ratio

1.75

95% CI 1.43–2.14

Weight lossvs Stable weight
pooled adjusted HR 1.75 (95% CI 1.43–2.14)

Further pooled results

OutcomeEstimate
All-cause mortality, overweight/obese subgroupHR 1.76 (95% CI 1.41–2.20)
All-cause mortality, not overweight/obese subgroupHR 1.90 (95% CI 1.14–3.14)
CV mortalityWeight lossvs No weight losspooled adjusted HR 1.64 (95% CI 1.18–2.28)

Original publication

Association of weight loss with cardiovascular or all-cause mortality in patients with heart failure: A meta-analysis. Int J Obes (Lond). Published 5 February 2024. doi:10.1038/s41366-024-01484-9

Composed by AI from the published abstract and checked against it. How Briefs are made →

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