Association of vertebral fractures with worsening degenerative changes of the spine: a longitudinal study
Main finding · Change in DHN summary index (unadjusted)Result — go to the resultDifference in change in DHN 0.38 95% CI 0.18–0.59Authors' conclusion
Beyond the established morbidity and mortality associated with VFs, our study suggests that VFs may also lead to worsening spine osteoarthritis.
Study context
- Population
- Participants of the Framingham Heart Study Offspring and Third Generation Multi-Detector CT study
- Participants
- 1,197 participants
- Exposure
- Prevalent VF vs no prevalent VF
- Prevalent VFn = 370
- Outcome
- Progression of facet joint osteoarthritis (FJOA) and intervertebral disc height narrowing (DHN), as change in summary indices
Main finding
Change in DHN summary index (unadjusted) · follow-up period
Difference in change in disc height narrowing (DHN)
0.38
95% CI 0.18–0.59
P < 0.001
Prevalent VFvs No prevalent VF
difference in change in DHN 0.38 (95% CI 0.18–0.59); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Difference in change in FJOA (95% CI) | P value | |
|---|---|---|---|
| Change in FJOA summary index, fully adjusted modelPrevalent VFvs No prevalent VF | 0.62 (−0.01 to 1.24) | P = 0.054 | |
| Change in FJOA summary index, fully adjusted modelSevere (grade 3) VFvs No prevalent VF | 4.48 (1.99–6.97) | ||
| −50510Difference (linear scale) |
- Change in facet joint osteoarthritis (FJOA) summary index, fully adjusted model — Greater change in FJOA summary index with increasing severity of prevalent VF
- linear trend p = .005
Original publication
Association of vertebral fractures with worsening degenerative changes of the spine: a longitudinal study. J Bone Miner Res. Published 17 October 2024. doi:10.
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