Association of reticulocyte-related indices with metabolic syndrome and its components: Evidence from the China National Health Survey
Authors' conclusion
This study identifies reticulocyte indices, particularly RET#, RET%, and IRF, as strongly associated with MetS, highlighting their potential utility in early screening and personalized risk stratification. These findings provide new insights into the role of erythropoiesis in metabolic health. Further longitudinal research is needed to elucidate the underlying mechanisms and validate the clinical applications of reticulocyte indices in managing MetS.
Study context
- Population
- Chinese adults aged 18 years and older, China National Health Survey
- Participants
- 6,098 adults
- Exposure
- Highest vs lowest quartile of reticulocyte-related indices
- Outcome
- Metabolic syndrome (MetS)
Methodological detailsmultivariable logistic regression, restricted cubic spline regression, mediation analysis
- Multivariable logistic regression
- Restricted cubic spline regression
- Mediation analysis
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Reticulocyte hemoglobin equivalent (RET-HE) and metabolic syndrome (MetS) components
- RET-HE significantly associated with low HDL-C and high waist circumference
Subgroups
- Stronger associations among younger individuals, males and those without obesity
Dose-response (restricted cubic spline (RCS))
- Nonlinear relationships between various reticulocyte-related indices and MetS
Mediation by inflammation
- Inflammation partially mediated the associations between reticulocyte-related indices and MetS
Original publication
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