Lipids & metabolic liver disease
Association of nonalcoholic fatty liver disease with new-onset atrial fibrillation stratified by age groups
Authors' conclusion
Patients with NAFLD had a higher risk of new-onset AF, which increased progressively with NAFLD severity, particularly in those aged 20-29 years.
Study context
- Population
- Participants of the 2009 Korean National Health Screening Program
- Participants
- 3,179,582 participants
- Exposure
- Nonalcoholic fatty liver disease (NAFLD) grades with or without advanced fibrosis vs no NAFLD
- Outcome
- Incident AF
- Follow-up
- Median 9.3 years
Main finding
As reported in the abstract
New-onset AF
Each group vs no NAFLDHazard ratio (95% CI)
Grade 1 NAFLD without advanced fibrosis
1.120(1.081–1.161)
Grade 1 NAFLD with advanced fibrosis
1.275(1.251–1.300)
Grade 2 NAFLD without advanced fibrosis
1.305(1.252–1.360)
Grade 2 NAFLD with advanced fibrosis
1.627(1.586–1.670)
- Patients diagnosed with new-onset atrial fibrillation (AF)
- 62,542
Observational data: associations, not effects.
Further findings
New-onset AF in multivariate model, by age
- Excess AF risk with NAFLD and advanced fibrosis remained significant, even in participants aged 20-39 years
- Multivariate model
Original publication
Association of nonalcoholic fatty liver disease with new-onset atrial fibrillation stratified by age groups. Cardiovasc Diabetol. Published 12 September 2024. doi:10.
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