Association of Maternal Thyroglobulin Antibody With Preterm Birth in Euthyroid Women
Main finding · PTBResult — go to the resultAdjusted odds ratio 1.16 95% CI 1.03–1.29Authors' conclusion
In euthyroid women, TgAb positivity was associated with a higher risk of PTB that mainly manifested as S-PTB and L-PTB. However, the clinical significance of these findings is limited.
Study context
- Population
- Euthyroid pregnant women enrolled in the first trimester
- Participants
- 58,247 women
- Exposure
- Thyroglobulin antibody (TgAb)-positive vs TgAb-negative
- Outcome
- PTB
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Adjusted odds ratio
1.16
95% CI 1.03–1.29
P = 0.01
TgAb-positivevs TgAb-negative
aOR 1.16 (95% CI 1.03–1.29); P = 0.01
Observational data: associations, not effects.
Further findings
| Outcome | aOR (95% CI) | |
|---|---|---|
| Spontaneous PTB (S-PTB) | 1.22 (1.06–1.39) | |
| Late PTB (L-PTB) | 1.17 (1.04–1.32) | |
| 0.512Adjusted odds ratio (log scale) |
TgAb concentration as continuous variable
- Consistent results with TgAb concentration as a continuous variable
PTB by first-trimester TSH stratum
- Associations statistically significant only among women with TSH 0.1–2.5 mIU/L
Original publication
Association of Maternal Thyroglobulin Antibody With Preterm Birth in Euthyroid Women. J Clin Endocrinol Metab. Published 25 February 2025. doi:10.
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