Association of Longitudinal Trajectory of Body Roundness Index With Cardiovascular Disease (CVD) Risk: Evidence From a Multicohort Study
Authors' conclusion
The BRI trajectories were significantly associated with CVD risk, independent of baseline BRI and BMI. This emphasizes the long-term and persistent effects of visceral fat accumulation and may provide a reference for personalized CVD risk assessment and early impact.
Study context
- Population
- Participants of three prospective cohort studies in the US, UK and China, 2004–20193 cohorts
- Comparison
- Body roundness index (BRI) trajectory groups: middle-increasing and inverse-U vs low-increasing
- Outcome
- CVD events
Methodological detailsmulticohort, multinational, latent class growth mixed models, Cox models
- Multicohort
- Multinational
- Latent class growth mixed models
- Cox models
Pooled result
As reported in the abstract
CVD risk
Risk of CVD (times higher)
1.25
95% CI 1.12–1.35
Middle-increasing
Risk of CVD (times higher)
1.86
95% CI 1.53–2.36
Inverse-U
Further pooled results
Dose-response of historical maximum BRI, AUC and time-weighted BRI with CVD
- Nonlinear risk of CVD in the dose-response relationship for all three
- P < 0.05
BRI growth rate and CVD by age
- Effect of BRI growth rate on CVD decreased with age
Original publication
Association of Longitudinal Trajectory of Body Roundness Index With CVD Risk: Evidence From a Multicohort Study. Obesity (Silver Spring). Published 2 October 2025. doi:10.
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