Association of Lipid Ratios With Cardiovascular Outcomes in Type 2 Diabetes: A Population Cohort Study
Authors' conclusion
Extremes of lipid ratios were associated with higher cardiovascular risk, suggesting that moderate ranges may be protective.
Study context
- Population
- Adults with T2D, Spanish NHS primary care electronic health records; mean follow-up 5.7 years (1.7 million person-years)
- Participants
- 303,199 adults
- Exposure
- Lipid ratios and outcomes, by sex
- Outcome
- Composite of all-cause mortality or hospitalisation for cerebrovascular or ischemic heart disease
- Follow-up
- Mean 5.7 years
Methodological detailsprimary care electronic health records, sex-specific Weibull models adjusted for clinical covariates
- Primary care electronic health records
- Sex-specific Weibull models adjusted for clinical covariates
Main finding
As reported in the abstract
- U-shaped associations between lipid ratios and outcomes
- Increased risk with higher ratios in both sexes, with slightly lower risk thresholds in women
- Very low values also linked to excess risk
Observational data: associations, not effects.
Original publication
Association of Lipid Ratios With Cardiovascular Outcomes in Type 2 Diabetes: A Population Cohort Study. Diabetes Obes Metab. Published 17 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →