Association of Growth Hormone Adherence and Growth Outcomes in Paediatric Patients: Results From a Clinical Registry
Authors' conclusion
Sustained high adherence (≥ 85%) to daily GH therapy was associated with clinically meaningful improvement in growth over 2 years.
Study context
- Population
- Paediatric patients with growth disorder receiving daily growth hormone (GH) therapy in a clinical registry; only those with consistent adherence classification across both yearsanalysed after 2 years
- Participants
- 74 patients
- Exposure
- High vs low adherence to daily GH therapy
- Outcome
- Change in height SD score (ΔHSDS)
- Follow-up
- 2 years
Methodological detailsclinical registry
- Clinical registry
Main finding
As reported in the abstract
ΔHSDS
Absolute difference
0.54
ΔHSDS
Spearman's rs
0.33
P < 0.01
positive correlation of ΔHSDS with high vs low adherence
Linear regression estimate
0.44
P = 0.03
improved ΔHSDS with High adherence
High adherence
0.87
mean
Low adherence
0.33
mean
Adherence > 110%
0.79
mean
Observational data: associations, not effects.
Original publication
Association of Growth Hormone Adherence and Growth Outcomes in Paediatric Patients: Results From a Clinical Registry. Clin Endocrinol (Oxf). Published 12 February 2026. doi:10.
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