Association of genetic risk and physical activity with incident type 2 diabetes
Main finding · Incident T2DResult — go to the resultHazard ratio 6.2 95% CI 3.97–9.6Authors' conclusion
These findings provide evidence of additive interactions between genetic risk and physical activity
Study context
- Population
- Participants of the All of Us Research Program with genetic and wearable device-derived physical activity data, without diabetes at baseline; median age 56 years (42–66)
- Participants
- 9,501 participants
- Exposure
- Genetic risk and physical activity levels
- Outcome
- Incident T2D (EHR-linked diagnostic codes); additive interaction of daily step counts and genetic risk
Methodological detailsAll of Us Research Program, wearable device-derived step counts, global polygenic score, multivariable Cox proportional hazards models, additive interaction (RERI)
- All of Us Research Program
- Wearable device-derived step counts
- Global polygenic score
- Multivariable Cox proportional hazards models
- Additive interaction (RERI)
Main finding
Incident T2D
Hazard ratio
6.2
95% CI 3.97–9.6
By group
High PA, low genetic risk
4.1 per 1000 person-years
CI 2.5–5.7
Low PA, high genetic risk
18.4
CI 15.2–21.6 · per 1000 person-years
Low PA, high genetic riskvs High PA, low genetic risk
HR 6.2 (95% CI 3.97–9.6)
As reported in the abstract
- Additive interaction: RERI
- 0.20 (95% CI, 0.04-0.36; P = .007)
- Excess risk attributed to the interaction
- 15% (95% CI, 2-27)
Observational data: associations, not effects.
Further findings
Interaction using device-based intensity metrics and self-reported PA
- Similar interaction patterns found
Original publication
Association of genetic risk and physical activity with incident type 2 diabetes. J Clin Endocrinol Metab. Published 27 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →