Association of DIO2 and MCT10 Polymorphisms With Persistent Symptoms in LT4-Treated Patients in the UK Biobank
Authors' conclusion
rs225014, rs225015, rs12885300, and rs17606253 could not explain changed psychological well-being, cognitive function, or cardiovascular risk factors in LT4-treated patients. Our findings do not support a gene-treatment interaction between these SNVs and LT4 treatment.
Study context
- Population
- UK Biobank participants: Levothyroxine (LT4)-treated patients with hypothyroidism and controls
- Exposure
- Single-nucleotide variations (SNVs) in DIO2 and MCT10 in LT4-treated patients vs controls
- Outcome
- Psychological well-being, cognitive function and cardiovascular risk factors (outcomes indicative of local tissue hypothyroidism)
Methodological detailspopulation-based, UK Biobank
- Population-based
- UK Biobank
Main finding
As reported in the abstract
Association of rs225014, rs225015, rs12885300, rs17606253 with outcomes in LT4-treated patients
- No association of the 4 SNVs with any outcome in LT4-treated patients, except minor rs225015 A allele with financial dissatisfaction
- Carrying the risk allele at the 4 SNVs did not amplify symptoms associated with LT4 treatment vs controls
- Adjusted for sex, age, sex-age interaction, genetic principal components 1 to 10
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| LT4 treatment vs controlsLT4-treated vs Controls · increased frequency of tiredness | P < 0.001 |
| LT4 treatment vs controlsLT4-treated vs Controls · decreased well-being factor score | P < 0.001 |
| LT4 treatment vs controlsLT4-treated vs Controls · increased reaction-time | P < 0.001 |
| LT4 treatment vs controlsLT4-treated vs Controls · increased BMI | P < 0.001 |
LT4 treatment vs controls
- LT4 treatment adversely associated with almost all outcomes vs controls
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association of DIO2 and MCT10 Polymorphisms With Persistent Symptoms in LT4-Treated Patients in the UK Biobank. J Clin Endocrinol Metab. Published 22 September 2023. doi:10.
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