Circulating miR-146a predicts glucocorticoid response in thyroid eye disease
Authors' conclusion
This is the first study investigating the role of pre-treatment circulating miR-21 and miR-146a to predict responsiveness to GC in TED. miR-146a emerged as a simple, objective, new marker of GC sensitivity that could be used to avoid ineffective administration of GC therapy to TED patients.
Study context
- Population
- Adults with active moderate-to-severe thyroid eye disease (TED) eligible for glucocorticoid (GC) therapy, treated with i.v. methylprednisolone (plus orbital radiotherapy if diplopia/duction worsened)
- Participants
- 30 adults
- Outcome
- Response to GC: decrease of ≥2 points in CAS or CAS <4/10
- Follow-up
- 24 weeks
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
Patients responding to GC
23
77%
miR-146a predicting responsiveness to GC (ROC analysis), PPV
100%
Observational data: associations, not effects.
Original publication
Circulating miR-146a predicts glucocorticoid response in thyroid eye disease. Eur Thyroid J. Published 22 September 2023. doi:10.
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