Association of cardiorespiratory fitness with high-resolution peripheral quantitative computed tomography (HR-pQCT) bone parameters in older adults: the Study of Muscle, Mobility and Aging (SOMMA)
Authors' conclusion
Associations of VO2peak with bone strength found in older men suggest VO2peak is associated with bone parameters in a sex-specific manner and mechanisms for these sex differences should be explored. Interventions aimed at increasing cardiorespiratory fitness should be evaluated for potential benefit to bone health among older men.
Study context
- Population
- Older adults in the Study of Muscle, Mobility and Aging (SOMMA); VO2peak by treadmill cardiopulmonary exercise testing at baseline; HR-pQCT and DXA after first annual follow-up (mean 1.2 ± 0.1 years)
- Participants
- 123 vs 188
- Exposure
- Higher vs lower VO2peak
- Menn = 123
- Womenn = 188
- Outcome
- Association of VO2peak (per SD) with HR-pQCT failure load
Methodological detailssex-stratified analyses, linear regression adjusted for confounders
- Sex-stratified analyses
- Linear regression adjusted for confounders
Main finding
As reported in the abstract
Men: tibial failure load, std β
0.26
p = 0.03
Men: radial failure load, std β
0.36
p = 0.007
Observational data: associations, not effects.
Original publication
Association of cardiorespiratory fitness with HR-pQCT bone parameters in older adults: the Study of Muscle, Mobility and Aging (SOMMA). Osteoporos Int. Published 12 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →