Association of Age at Type 2 Diabetes Onset With Diabetes Progression
Authors' conclusion
Younger-onset diabetes was associated with greater adiposity, lower HDL, and better SBP and eGFR at onset, with differences largely persisting during follow-up. During follow-up, glycemia increased slightly faster in individuals with younger-onset diabetes.
Study context
- Population
- Participants in the Kerala Diabetes Prevention Program (K-DPP) and U.S. Diabetes Prevention Program (US-DPP) who developed T2D during the trial; US-DPP n=802 (mean age 52.6 years), K-DPP n=146 (mean age 47.7 years)802 US-DPP, 146 K-DPP
- Comparison
- Younger vs older age at T2D onset
- Primary endpoint
- Disease progression: changes in glycemic control (FPG, HbA1c) and clinical biomarkers (TG, HDL, LDL, BMI, blood pressure, eGFR) by age at onset
- Follow-up
- Diabetes onset and end (mean 7.9 and 7.6 years for US-DPP and K-DPP)
Methodological detailscohort analysis, linear and mixed-effects regression
- Cohort analysis
- Linear and mixed-effects regression
Primary result
As reported in the abstract
Glycemia (FPG, HbA1c) by age at onset
- Fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) at onset not associated with age at onset (fully adjusted models)
- FPG and HbA1c increased faster in younger-onset participants; not significant in K-DPP
- Fully adjusted models
Further findings
BMI · onset and end of follow-up
- Younger-onset had higher BMI at onset and end of follow-up, with relatively small BMI change over time in US-DPP
Estimated glomerular filtration rate (eGFR), HDL and systolic blood pressure (SBP)
- US-DPP: younger onset associated with higher eGFR and lower HDL and SBP
- K-DPP: similar directions; association with HDL nonsignificant
- SBP fell slightly in older-onset US-DPP participants during follow-up but not in younger-onset
Original publication
Association of Age at Type 2 Diabetes Onset With Diabetes Progression. Diabetes Care. Published 7 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →