Lipids & metabolic liver disease
Association of dynamic change of triglyceride-glucose index during hospital stay with all-cause mortality in critically ill patients: a retrospective cohort study from MIMIC IV2.0
Authors' conclusion
Dynamic change of TyG during hospital stay is associated with in-hospital and 1-year all-cause mortality, and may be superior to the effect of baseline TyG index.
Study context
- Population
- Critically ill patients, MIMIC-IV 2.0 critical care dataset13,674 TyG measurements
- Participants
- 8,835 patients
- Exposure
- Dynamic change of TyG index during hospital stay, by quartile
- Outcome
- All-cause mortality
- Follow-up
- 1 year
Methodological detailspropensity score matching
- Propensity score matching
Main finding
As reported in the abstract
1-year all-cause mortality
Deaths within first year
2477
29.52%
Nearly linear association between TyGVR and 1-year all-cause mortality (restricted cubic spline)
P for non-linear = 0.909
P for overall = 0.019
Observational data: associations, not effects.
Secondary outcomes
In-hospital all-cause mortality
- Nearly linear association between TyGVR and in-hospital all-cause mortality (restricted cubic spline)
- P for non-linear = 0.449, P for overall = 0.004
All-cause deaths over follow-up · follow-up period
- Total all-cause deaths
- 3010 (35.87%)
AUC of severity of illness scores for all-cause mortality
- AUC of conventional severity of illness scores significantly improved with addition of TyG index and TyGVR
Subgroup analysis
- Results basically consistent in subgroup analysis
Original publication
Association of dynamic change of triglyceride-glucose index during hospital stay with all-cause mortality in critically ill patients: a retrospective cohort study from MIMIC IV2.0. Cardiovasc Diabetol. Published 17 June 2023. doi:10.
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