Association between weight‐adjusted‐waist index and incident carotid atherosclerosis in the general adult population in Chinese communities: Evidence from the REACTION cohort study
Authors' conclusion
High WWI is associated with a higher risk of CAS, which implies that WWI might be a reliable indicator to identify high-risk populations of CAS among the general adult population in Chinese communities.
Study context
- Population
- General adults in Chinese communities (REACTION study) attending health examinations in 2012 and 2018, no history of carotid atherosclerosis (CAS)
- Participants
- 4,671 adults
- Exposure
- WWI tertiles T2 and T3 vs T1
- Outcome
- Incident carotid atherosclerosis (CAS)
- Follow-up
- Median 6.62 years
Methodological detailscommunity-based, Cox proportional hazard models, subgroup and sensitivity analyses
- Community-based
- Cox proportional hazard models
- Subgroup and sensitivity analyses
Main finding
As reported in the abstract
Incident CAS
Hazard ratio (95% CI)
Q2vs Q1
1.171(1.066–1.287)
Q3vs Q1
1.473(1.333–1.627)
Observational data: associations, not effects.
Further findings
Characteristics of CAS vs non-CAS participants
- Median age, CAS vs non-CAS (years)
- 56 vs. 52; p < 0.001
- Male proportion, CAS vs non-CAS
- 38.1% vs. 17.5%; p < 0.001
Original publication
Association between weight‐adjusted‐waist index and incident carotid atherosclerosis in the general adult population in Chinese communities: Evidence from the REACTION cohort study. Diabetes Obes Metab. Published 9 June 2025. doi:10.
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