Association between vestibular dysfunction and osteoporosis in adults: a systematic review and meta-analysis
Pooled result · Osteoporosis risk in BPPV vs normal controls, Chinese studies subgroup (4 studies)Result — go to the resultOdds ratio 3.42 95% CI 2.12–5.50Authors' conclusion
A close bidirectional association may exist between vestibular dysfunction, particularly BPPV, and osteoporosis in adults.
Study context
- Population
- Adults with vestibular dysfunction (e.g. Benign paroxysmal positional vertigo (BPPV), Meniere's disease) or osteoporosis; studies published January 2000 to December 202533 studies
- Comparison
- Adults with vs without vestibular dysfunction (osteoporosis risk); adults with vs without osteoporosis (vestibular dysfunction risk)
- Outcome
- Osteoporosis risk in BPPV vs normal controls, Chinese studies subgroup (4 studies)
Methodological detailsrandom-effects model for pooled prevalence, subgroup analysis by country
- Random-effects model for pooled prevalence
- Subgroup analysis by country
Pooled result
As reported in the abstract
Odds ratio
3.42
95% CI 2.12–5.50
P < 0.00001
BPPVvs Normal controls
OR 3.42 (95% CI 2.12–5.50); P < 0.00001
Further pooled results
| Outcome | OR (95% CI) | |
|---|---|---|
| BPPV risk, osteoporosis vs non-osteoporosis controls (three large-sample studies; analysed descriptively)Osteoporosisvs Non-osteoporosis | 1.77 (1.69–1.86) | |
| BPPV risk, osteoporosis vs non-osteoporosis controls (three large-sample studies; analysed descriptively)Osteoporosisvs Non-osteoporosis | 1.28 (1.15–1.42) | |
| BPPV risk, osteoporosis vs non-osteoporosis controls (three large-sample studies; analysed descriptively)Osteoporosisvs Non-osteoporosis | 2.03 (1.52–2.70) | |
| MD history risk, osteoporosisvs non-osteoporosis controls (one large-sample study) | 1.88 (1.76–2.02) | |
| 0.20.5125Odds ratio (log scale) |
- BPPV risk, osteoporosis vs non-osteoporosis controls (three large-sample studies; analysed descriptively): moderate heterogeneity persisting after sensitivity analysis (I2 = 58%, P = 0.03); 7 studies analyzed descriptively
Prevalence of BPPV in the osteoporotic population (pooled, random-effects)
- Prevalence of BPPV in the osteoporotic population, approximately
- 8.3% (95% CI 3.8-14.5%; I2 = 97%, P < 0.00001)
- Random-effects model
Prevalence of abnormal Romberg test results in the osteoporotic population (pooled, random-effects)
- Prevalence of abnormal Romberg test in the osteoporotic population
- 10.7% (95% CI 2.0-46.8%; I2 = 100%, P < 0.00001)
- Random-effects model
Prevalence of osteoporosis in BPPV (pooled, random-effects)
- Pooled prevalence of osteoporosis in BPPV
- 17.4% (95% CI 9.1-31.5%; I2 = 96%, P < 0.00001)
- Random-effects model
Original publication
Association between vestibular dysfunction and osteoporosis in adults: a systematic review and meta-analysis. Osteoporos Int. Published 8 June 2026. doi:10.
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