The association between triglyceride glucose-waist height ratio index and cardiometabolic multimorbidity among Chinese middle-aged and older adults: a national prospective cohort study
Authors' conclusion
This study suggests that TyG-WHtR independently predicts CMM risk. The linear dose-response relationship highlight the potential utility of TyG-WHtR in early risk assessment and prevention strategies for CMM.
Study context
- Population
- Chinese adults aged ≥ 45 years in the 2011–2020 waves of China Health and Retirement Longitudinal Study (CHARLS)
- Participants
- 4,393 adults
- Exposure
- TyG-WHtR index quartiles Q2–Q4 vs lowest quartile
- Outcome
- Incident cardiometabolic multimorbidity (CMM)
- Follow-up
- Median 9 years
Methodological detailsnational
- National
Main finding
As reported in the abstract
CMM risk by TyG-WHtR quartile
Each group vs Q1Hazard ratio (95% CI)
Q2
1.75(1.18–2.6)
Q3
2.33(1.58–3.43)
Q4
3.13(2.08–4.7)
- Participants who developed cardiometabolic multimorbidity (CMM)
- 413 (9.4%)
Observational data: associations, not effects.
Further findings
Cumulative TyG-WHtR
- Elevated cumulative TyG-WHtR independently increased CMM risk
Dose-response (restricted cubic spline (RCS))
- Positive linear relationship between TyG-WHtR index and CMM incidence
Predictive performance
- Baseline and cumulative TyG-WHtR significantly improved net reclassification improvement (NRI)/integrated discrimination improvement (IDI) and AUC
Sensitivity analyses
- Sensitivity analyses corroborated the primary findings
Original publication
The association between triglyceride glucose-waist height ratio index and cardiometabolic multimorbidity among Chinese middle-aged and older adults: a national prospective cohort study. Cardiovasc Diabetol. Published 2 September 2025. doi:10.
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