Association between dynamic changes in the triglyceride-glucose index and prognosis in patients with acute ST-segment elevation myocardial infarction
Authors' conclusion
Distinct TyG trajectories after STEMI are associated with long-term prognosis. A persistently high TyG trajectory indicates elevated cardiovascular risk, suggesting its potential role in secondary prevention.
Study context
- Population
- STEMI patients undergoing PCI; Triglyceride-Glucose (TyG) index measured at baseline and 3, 6, 9 and 12 months post-discharge
- Participants
- 1,092 patients
- Exposure
- TyG index trajectories after STEMI: rapid decline vs moderate vs persistently high
- Persistently highn = 92reference
- Moderaten = 196
- Rapid declinen = 804
- Outcome
- Major adverse cardiovascular events (MACE)
- Follow-up
- Five years
Methodological detailsgroup-based trajectory modeling
- Group-based trajectory modeling
Main finding
As reported in the abstract
MACE incidence
- TyG trajectory was an independent predictor of outcomes
- Rapid decline vs Persistently high: P < 0.001
Observational data: associations, not effects.
Original publication
Association between dynamic changes in the triglyceride-glucose index and prognosis in patients with acute ST-segment elevation myocardial infarction. Cardiovasc Diabetol. Published 1 September 2025. doi:10.
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