Association between the triglyceride–glucose index and the risk of mortality among patients with chronic heart failure: results from a retrospective cohort study in China
An erratum to this article was published (Cardiovasc Diabetol, 15 Sep 2023 ↗)
Main finding · All-cause deathResult — go to the resultHazard ratio 1.84 95% CI 1.61–2.10Authors' conclusion
The TyG index was significantly associated with the risk of mortality, suggesting that it may be a reliable and valuable predictor for risk stratification and an effective prognostic indicator in patients with CHF.
Study context
- Population
- Consecutive patients with chronic heart failure (CHF), China
- Participants
- 6,697 patients
- Exposure
- Highest vs lowest triglyceride-glucose (TyG) index tertile
- Outcome
- All-cause death and CV death
- Follow-up
- Median 3.9 years
Methodological detailsconsecutive patients, tertiles of TyG index
- Consecutive patients
- Tertiles of TyG index
Main finding
All-cause death
Hazard ratio
1.84
95% CI 1.61–2.10
P < 0.001 for trend
By group
Lowest tertile
50.61 per 1000 person-years
Middle tertile
64.64 per 1000 person-years
Highest tertile
92.25 per 1000 person-years
As reported in the abstract
- Total all-cause deaths
- 2158 (32.2%)
Observational data: associations, not effects.
Further findings
Per 1000 person-years
| Outcome | Lowest tertile | Middle tertile | Highest tertile | HR (95% CI) | P value | |
|---|---|---|---|---|---|---|
| CV death · median follow-up 3.9 yearsHighest tertilevs Lowest tertileMultivariate Cox regression · co-primary outcome | 29.05 | 39.40 | 57.21 | 1.94 (1.63–2.30) | P for trend < 0.001 | |
| 0.512Hazard ratio (log scale) |
- Cardiovascular (CV) death — Total CV deaths
- 1305 (19.5%)
All-cause death by subgroup (metabolic syndrome; HF with preserved ejection fraction)
- Predictive ability of TyG index more prominent with metabolic syndrome and HFpEF phenotype
- both P for interaction < 0.05
Incremental prediction of all-cause death, adding TyG index to established model
- C-statistic, established model vs + TyG index
- 0.710 vs. 0.723, P < 0.01
- Integrated discrimination improvement
- 0.011, P < 0.01
- Net reclassification improvement
- 0.273, P < 0.01
- Clinical net benefit, probability range
- 0.07-0.36
Original publication
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