Association between triglyceride-glucose index and in-hospital mortality in critically ill patients with sepsis: analysis of the MIMIC-IV database
Main finding · In-hospital mortalityResult — go to the resultOdds ratio 1.440 95% CI 1.106–1.875Authors' conclusion
Our study indicates that a high TyG index is associated with an increased in-hospital mortality in critically ill sepsis patients. Larger prospective studies are required to confirm these findings.
Study context
- Population
- Critically ill patients with sepsis, MIMIC-IV 2.2 database56.88% men
- Participants
- 1,257 patients
- Exposure
- Triglyceride-glucose (TyG) index and in-hospital mortality
- Outcome
- In-hospital all-cause mortality
Methodological detailsobservational, MIMIC-IV database
- Observational
- MIMIC-IV database
Main finding
In-hospital mortality
Odds ratio
1.440
95% CI 1.106–1.875
P = 0.00673
TyG index
OR 1.440 (95% CI 1.106–1.875); P = 0.00673
As reported in the abstract
- In-hospital mortality (overall)
- 21.40%
Observational data: associations, not effects.
Further findings
Intensive care unit (ICU) mortality
| OR (95% CI) | P value | ||
|---|---|---|---|
| TyG indexMultivariate logistic regression | 1.597 (1.188–2.147) | P = 0.00266 | |
| 0.512Odds ratio (log scale) |
| Outcome | OR (95% CI) | P value |
|---|---|---|
| 28-day mortality · multivariate logistic regression | 1.391 (1.52–1.678) | P = 0.01414 |
- 28-day mortality — 28-day mortality (overall)
- 26.17%
- ICU mortality — ICU mortality (overall)
- 15.43%
Sensitivity analyses
- Effect size and direction consistent across subgroups
- Machine learning: TyG index an important feature for sepsis outcomes
Original publication
Association between triglyceride-glucose index and in-hospital mortality in critically ill patients with sepsis: analysis of the MIMIC-IV database. Cardiovasc Diabetol. Published 8 November 2023. doi:10.
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