The association between triglyceride glucose-body mass index and all-cause mortality in critically ill patients with atrial fibrillation: a retrospective study from Medical Information Mart for Intensive Care IV (MIMIC-IV) database
Authors' conclusion
In critically ill patients with AF, a lower TyG-BMI level is significantly associated with a higher risk of 30-day, 90-day, 180-day and 365-day all-cause mortality. TyG-BMI index could be used as a valid indicator for grading and treating patients with AF in the ICU.
Study context
- Population
- Critically ill patients with atrial fibrillation (AF) in the ICU, MIMIC-IV database; mean age 73.26 ± 11.87 years, 62.0% male
- Participants
- 2,509 patients
- Exposure
- TyG-BMI index quartiles
- Outcome
- 30-day and 365-day all-cause mortality
- Follow-up
- 30 days and 365 days
Methodological detailsMIMIC-IV database
- MIMIC-IV database
Main finding
As reported in the abstract
All-cause mortality
- Lower TyG-BMI associated with higher risk of 30-day and 365-day all-cause mortality (Kaplan-Meier)
- log-rank P < 0.001
- L-shaped relationship (restricted cubic splines (RCS)); inflection point for 30-day mortality
- 223.60
- Inflection point for 365-day mortality
- 255.02
- Above vs below inflection point: 1.8% lower risk of 30-day all-cause mortality
- HR 0.982, 95% CI 0.9676-0.988
- Above vs below inflection point: 1.1% lower risk of 365-day all-cause mortality
- HR 0.989, 95% CI 0.986-0.991
Observational data: associations, not effects.
Secondary outcomes
90-day and 180-day all-cause mortality
- Lower TyG-BMI associated with higher risk (Kaplan-Meier)
- log-rank P < 0.001
- Risk significantly higher in lowest TyG-BMI quartile (Cox regression)
Original publication
The association between triglyceride glucose-body mass index and all-cause mortality in critically ill patients with atrial fibrillation: a retrospective study from MIMIC-IV database. Cardiovasc Diabetol. Published 10 February 2024. doi:10.
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