Association Between Time in Range and Advanced Cardiovascular‐Kidney‐Metabolic Syndrome in Older Adults With Type 2 Diabetes
Main finding · Advanced CKM syndrome per 1-SD decrease in TIRResult — go to the resultOdds ratio 1.28 95% CI 1.16–1.42Authors' conclusion
Lower TIR was associated with advanced CKM syndrome
Study context
- Population
- Adults aged ≥60 years with T2D; advanced cardiovascular-kidney-metabolic (CKM) syndrome = stages 3–4 per American Heart Association Presidential Advisory
- Participants
- 2,497 adults
- Exposure
- Time in range (TIR) categories and advanced CKM syndrome
- Outcome
- Advanced CKM syndrome (stages 3-4)
Main finding
Advanced CKM syndrome per 1-SD decrease in TIR
Odds ratio
1.28
95% CI 1.16–1.42
1-SD decrease in TIR
OR 1.28 (95% CI 1.16–1.42)
Per 1-SD decrease in TIR, as printed
As reported in the abstract
- Lower TIR with advanced vs non-advanced CKM syndrome
- P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Prevalence of advanced CKM syndrome across TIR categoriesTIR 50%-70%vs TIR >70% | 1.40 (1.12–1.75) | |
| 0.512Odds ratio (log scale) |
| Outcome | P value |
|---|---|
| Prevalence of advanced CKM syndrome across TIR categoriesTIR categories · prevalence increased progressively from >70% to ≤50% | P for trend < 0.001 |
Safety
Hypoglycaemia exposure
- Higher TIR was not associated with increased hypoglycemia exposure
Original publication
Association Between Time in Range and Advanced Cardiovascular‐Kidney‐Metabolic Syndrome in Older Adults With Type 2 Diabetes. Diabetes Obes Metab. Published 22 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →