Association between the C-reactive protein-triglyceride glucose index and new-onset coronary heart disease among metabolically heterogeneous individuals
Authors' conclusion
The CTI demonstrated a significant statistical association with new-onset CHD diagnoses among metabolically heterogeneous individuals. Its combination with the CALLY index further enhanced diagnostic discrimination, supporting its potential utility in individualized identification and refined clinical assessment.
Study context
- Population
- Metabolically heterogeneous individuals, categorized into 4 obesity and metabolic phenotypes
- Participants
- 2,237 individuals
- Exposure
- Association of CTI with new-onset coronary heart disease (CHD) across 4 obesity–metabolic phenotypes
- Outcome
- New-onset CHD
Main finding
As reported in the abstract
Association between CTI and new-onset CHD
- Robust association between CTI and new-onset CHD
- P < 0.001
Observational data: associations, not effects.
Further findings
Mediation by CALLY index
- CALLY index was a partial mediator of the CTI–CHD relationship
High CTI (≥ 9.887) and low CALLY index (< 1.221) and CHD diagnosis at admission
- Strongest association with CHD, OR
- 2.36 (95% CI 2.06-2.69)
Discrimination for new-onset CHD with CTI + CALLY
- Integration of CTI and CALLY significantly associated with stronger discriminatory ability
Original publication
Association between the C-reactive protein-triglyceride glucose index and new-onset coronary heart disease among metabolically heterogeneous individuals. Cardiovasc Diabetol. Published 1 August 2025. doi:10.
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