Association between the atherogenic index of plasma and adverse long-term prognosis in patients diagnosed with chronic coronary syndrome

Cardiovasc DiabetolPublished Cohort study

Main finding · MACE incidenceResult — go to the resultAdjusted hazard ratio 7.892 95% CI 1.818–34.269

Authors' conclusion

Our data indicate, for the first time, that AIP is independently associated with poor long-term prognosis in patients suffering from CCS. The optimal AIP cut-off value for predicting clinical MACE among CCS patients was 0.24.

Study context

Population
Patients with chronic coronary syndrome (CCS) who underwent coronary angiography; Atherogenic Index of Plasma (AIP) = log (TG/HDL-C)
Participants
404 patients
Exposure
AIP quartiles Q4 vs Q1–Q3
Outcome
MACE
Follow-up
Median 35 months

Main finding

MACE incidence · median 35 months

Adjusted hazard ratio

7.892

95% CI 1.818–34.269

P = 0.006

By group

Q4vs Q1
aHR 7.892 (95% CI 1.818–34.269); P = 0.006

As reported in the abstract

Major adverse cardiovascular events (MACE) events overall
88
Q4 had the highest risk of MACE on Kaplan-Meier curves
log-rank P = 0.014

Observational data: associations, not effects.

Further findings

Optimal AIP cut-off for predicting MACE (ROC)

Optimal AIP cut-off
0.24

Original publication

Association between the atherogenic index of plasma and adverse long-term prognosis in patients diagnosed with chronic coronary syndrome. Cardiovasc Diabetol. Published 21 September 2023. doi:10.1186/s12933-023-01989-z

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