Association between myosteatosis and bone mineral density in postmenopausal women
Authors' conclusion
Postmenopausal women with higher-quality abdominal muscles exhibited higher BMD at all sites and a lower prevalence of osteoporosis, independent of abdominal adiposity and total muscle mass.
Study context
- Population
- Postmenopausal women who underwent abdominal computed tomography (CT) during health check-ups259 (12.8%) with osteoporosis
- Participants
- 2,021 women
- Exposure
- Tertiles of the normal attenuation muscle area (NAMA)/total abdominal muscle area (TAMA) index
- Outcome
- Association between abdominal muscle quality (myosteatosis on CT, NAMA/TAMA index) and BMD
Methodological detailsabdominal CT at health check-ups, adjusted for confounders
- Abdominal CT at health check-ups
- Adjusted for confounders
Main finding
As reported in the abstract
BMD by NAMA/TAMA index tertile (adjusted)
- Lumbar spine bone mineral density (BMD) increased significantly with higher NAMA/TAMA index tertiles
- p < 0.001
- Femoral neck BMD increased significantly with higher NAMA/TAMA index tertiles
- p = 0.011
- Total hip BMD increased significantly with higher NAMA/TAMA index tertiles
- p < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Lowest tertile | Middle tertile | Highest tertile | aOR (95% CI) | |
|---|---|---|---|---|---|
| OsteoporosisHighest tertilevs Lowest tertileEven after adjusting for both abdominal fat and muscle area | 15.3% | 12.2% | 11.0% | 0.58 (0.38–0.87) | |
| 0.20.5125Adjusted odds ratio (log scale) |
- Osteoporosis — Prevalence tended to decrease with increasing tertiles
- p = 0.051
Vertebral fractures
- Prevalence decreased with increasing tertiles of the NAMA/TAMA index
- P = 0.005
Muscle measures, osteoporosis vs no osteoporosis
- TAMA, skeletal muscle area (SMA), NAMA lower in osteoporosis group
- P < 0.001
- NAMA/TAMA index lower in osteoporosis group
- P = 0.012
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association between myosteatosis and bone mineral density in postmenopausal women. Osteoporos Int. Published 2 July 2026. doi:10.
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