Association between glycemic status and age-related macular degeneration: A nationwide population-based cohort study
Authors' conclusion
The incidence of dry and wet AMD increased among diabetes patients compared to the normal glycemic status group. These risks increased when the duration of diabetes was 5 years or more. The risk of wet AMD was increased among new-onset diabetes patients. These results suggest that high blood glucose levels without treatment might induce the vision-threatening condition of wet AMD, emphasizing the importance of early blood glucose management.
Study context
- Population
- Adults ≥ 45 years, AMD-free at 2009 health checkups, South Korea health insurance claims database; observed 2011–2018
- Participants
- 2,103,604 adults
- Exposure
- Glycemic status categories vs normal glycemic status
- Outcome
- Incident dry AMD (without choroidal neovascularization) and wet AMD (with choroidal neovascularization)
- Follow-up
- January 1, 2011, to December 31, 2018
Methodological detailsnationwide, population-based
- Nationwide
- Population-based
Main finding
As reported in the abstract
Dry AMD (n = 36,271, 1.72%)
Each group vs normalAdjusted hazard ratio (CI)
Diabetes < 5 years
1.192(1.141–1.245)
Diabetes ≥ 5 years
1.294(1.242–1.349)
Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | |
|---|---|---|
| Wet AMD (n = 12,912, 0.61%)New-onset diabetesvs NormalNo HR printed for IFG | 1.103 (1.011–1.203) | |
| Wet AMD (n = 12,912, 0.61%)Diabetes < 5 yearsvs NormalNo HR printed for IFG | 1.252 (1.167–1.344) | |
| Wet AMD (n = 12,912, 0.61%)Diabetes ≥ 5 yearsvs NormalNo HR printed for IFG | 1.506 (1.413–1.605) | |
| 0.512Hazard ratio (log scale) |
AMD by subgroup
- HR of AMD significantly increased among participants ≤ 65 years old and those without hypertension
Original publication
Association between glycemic status and age-related macular degeneration: A nationwide population-based cohort study. Diabetes Metab. Published 16 March 2023. doi:10.
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