The association between glycaemic control, normal weight and long‐term macrovascular outcomes in people with type 2 diabetes in China: A retrospective study
Authors' conclusion
Index and sustained glycaemic control and normal BMI were associated with significant risk reduction in 3P-MACE among Chinese patients with T2D.
Study context
- Population
- Adults with T2D and ≥1 HbA1c and body mass index (BMI) record, 2007–2016, Yinzhou district, Ningbo, Chinaindex population
- Participants
- 5,757 adults
- Exposure
- Glycaemic control and normal BMI vs neither glycaemic control nor normal BMI
- Outcome
- 3-point MACE (3P-MACE)
- Follow-up
- Median 6.8 years
Methodological detailsregional health information system, Cox proportional hazards models
- Regional health information system
- Cox proportional hazards models
Main finding
As reported in the abstract
3P-MACE, index population
Glycaemic control and normal BMI vs Neither glycaemic control nor normal BMIAdjusted hazard ratio (95% CI)P value
HbA1c cutoff <7.0%
0.73(0.62–0.86)
P < 0.001HbA1c cutoff ≤6.5%
0.76(0.64–0.90)
P = 0.001- Experienced 3P-MACE (index population)
- 1188 [20.6%]
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | P value | |
|---|---|---|---|
| 3P-MACE, sustained population (n = 5513): sustained glycaemic control and normal BMIGlycaemic control and normal BMIvs Neither glycaemic control nor normal BMISustained; HbA1c cutoff <7.0% | 0.67 (0.49–0.91) | P = 0.012 | |
| 3P-MACE, sustained population (n = 5513): sustained glycaemic control and normal BMIGlycaemic control and normal BMIvs Neither glycaemic control nor normal BMISustained; HbA1c cutoff ≤6.5% | 0.69 (0.50–0.94) | P = 0.020 | |
| 0.512Adjusted hazard ratio (log scale) |
Original publication
The association between glycaemic control, normal weight and long‐term macrovascular outcomes in people with type 2 diabetes in China: A retrospective study. Diabetes Obes Metab. Published 10 November 2025. doi:10.
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