Association Between Free Triiodothyronine and Diabetic Peripheral Neuropathy in Euthyroid Patients With Type 2 Diabetes
Authors' conclusion
Low FT3 is a risk factor of DPN among euthyroid patients with type 2 diabetes.
Study context
- Population
- Hospitalized euthyroid patients with T2D, Zhongshan Hospital, Fudan University
- Participants
- 1,422 patients
- Exposure
- Diabetic peripheral neuropathy (DPN) vs no DPN
- DPNn = 519
- Outcome
- Serum FT3
Methodological detailssingle-centre, hospitalized patients, Mendelian randomization analysis
- Single-centre
- Hospitalized patients
- Mendelian randomization analysis
Main finding
As reported in the abstract
P < 0.001
- Inverse association of serum free triiodothyronine (FT3) with DPN risk remained significant after multivariate adjustment
- P < 0.05
Observational data: associations, not effects.
Further findings
- DPN prevalence
- 36.5% · 519
FT3 and electromyographic measures in DPN
- FT3 inversely correlated with DML and DSL, positively with compound muscle action potential (CMAP), sensory nerve action potential (SNAP) and nerve conduction velocity (NCV) of all nerves measured
- all P < .05
Clinical characteristics, DPN vs no DPN
- DPN: longer diabetes duration, poorer glucose control, lower BMI, more DR, diabetic nephropathy and CVD
- all P < .05
Original publication
Association Between Free Triiodothyronine and Diabetic Peripheral Neuropathy in Euthyroid Patients With Type 2 Diabetes. J Clin Endocrinol Metab. Published 27 May 2025. doi:10.
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