Association between estimated glucose disposal rate and cardiovascular mortality across the spectrum of glucose tolerance in the US population
Authors' conclusion
In the general population, the association between reduced eGDR and all-cause and cardiovascular mortality was independently significant, contributing to the identification of individuals at high risk for different levels of glucose tolerances.
Study context
- Population
- Individuals aged 45–79 years, NHANES cycles 1999 to 2010, across levels of glucose tolerance
- Participants
- 11,656 individuals
- Exposure
- Estimated glucose disposal rate (eGDR) categories 4-6, 6-8 and >8 vs ≤4 mg/kg/min
- Outcome
- CVD mortality
- Follow-up
- Median 12.8 years
Methodological detailspopulation-based, Cox proportional hazards and Fine and Gray models
- Population-based
- Cox proportional hazards and Fine and Gray models
Main finding
As reported in the abstract
CVD mortality (777 deaths)
Each group vs eGDR ≤4Hazard ratio (CI)
eGDR 4-6
0.44(0.33–0.57)
eGDR 6-8
0.45(0.34–0.59)
eGDR >8
0.30(0.23–0.40)
Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | |
|---|---|---|
| All-cause mortality (2852 deaths) · median follow-up 12.8 yearseGDR 4-6vs eGDR ≤4Cox proportional hazards model | 0.61 (0.52–0.72) | |
| All-cause mortality (2852 deaths) · median follow-up 12.8 yearseGDR 6-8vs eGDR ≤4Cox proportional hazards model | 0.61 (0.52–0.72) | |
| All-cause mortality (2852 deaths) · median follow-up 12.8 yearseGDR >8vs eGDR ≤4Cox proportional hazards model | 0.46 (0.39–0.55) | |
| 0.20.5125Hazard ratio (log scale) |
Shape of eGDR–all-cause mortality relationship
- U-shaped relationship; inflection point at eGDR (mg/kg/min)
- 9.54
Original publication
Association between estimated glucose disposal rate and cardiovascular mortality across the spectrum of glucose tolerance in the US population. Diabetes Obes Metab. Published 18 September 2024. doi:10.
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