Association between different insulin resistance surrogates and all-cause mortality in patients with coronary heart disease and hypertension: NHANES longitudinal cohort study
Authors' conclusion
The relationship between HOMA-IR and all-cause mortality was U-shaped in patients with CHD and hypertension. HOMA-IR was a reliable predictor of all-cause mortality in this population.
Study context
- Population
- Patients with coronary heart disease and hypertension, NHANES 2001–2018455 died
- Participants
- 1,126 patients
- Exposure
- Homeostatic model assessment of IR (HOMA-IR) below vs above inflection point 3.59
- Outcome
- All-cause mortality
- Follow-up
- Median 76 months
Methodological detailsNHANES 2001-2018 linked to National Death Index, multivariate Cox regression, restricted cubic splines
- NHANES 2001-2018 linked to National Death Index
- Multivariate Cox regression
- Restricted cubic splines
Main finding
As reported in the abstract
RCS showed HOMA-IR had a segmented effect on all-cause mortality; inflection point (statistically significant)
3.59
Observational data: associations, not effects.
Further findings
Prediction of survival status by HOMA-IR (ROC and calibration curves)
- AUC
- 0,812
Interactions with stratified variables (age, gender, diabetes, cancer, hypoglycemic and lipid-lowering drug use)
- No interactions between HOMA-IR and stratified variables were found
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →