Association between diabetes and stress-induced hyperglycemia with skeletal muscle gene expression of INSR in critically ill patients: A prospective cohort study
Authors' conclusion
In conclusion, INSR was downregulated in the skeletal muscle of critically ill patients with stress-induced hyperglycemia.
Study context
- Population
- Critically ill patients, April 2018 to September 2018; vastus muscle biopsies
- Participants
- 50 patients
- Exposure
- Diabetes vs no diabetes; stress-induced hyperglycemia markers
- Outcome
- Skeletal muscle gene expression of INSR (RT-qPCR)
Main finding
As reported in the abstract
Skeletal muscle INSR expression by diabetes status
- No significant differences in skeletal muscle gene expression between patients with or without diabetes
Observational data: associations, not effects.
Further findings
GV ≥ 40 mg/dl vs GV < 40 mg/dl
INSR expression by glycemic variability · downregulation of INSR with GV ≥ 40 mg/dl
P = 0.045
Glycemic gap ≥ 80 mg/dl vs Glycemic gap < 80 mg/dl
INSR expression by glycemic gap · same pattern (downregulation) with glycemic gap ≥ 80 mg/dl
P = 0.015
INSR expression by hypoglycemia 〈 70 mg/dl or hyperglycemia 〉 140 mg/dl
- No differences in gene expression by presence of hypoglycemia or hyperglycemia
Original publication
Association between diabetes and stress-induced hyperglycemia with skeletal muscle gene expression of INSR in critically ill patients: A prospective cohort study. Diabetes Metab. Published 18 October 2023. doi:10.
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