Association between cumulative changes of the triglyceride glucose index and incidence of stroke in a population with cardiovascular-kidney-metabolic syndrome stage 0–3: a nationwide prospective cohort study
Authors' conclusion
Elevated cumTyG was associated with an increased risk of stroke events in the population of CKM syndrome stages 0-3. Long-term dynamic monitoring of changes of TyG may help in the early identification of patients at high risk of developing stroke in the individuals with CKM syndrome stages 0-3.
Study context
- Population
- Participants with Cardiovascular-Kidney-Metabolic (CKM) syndrome stages 0–3, China Health and Retirement Longitudinal Study (CHARLS), 2011–2015280 developed stroke
- Participants
- 4,700 participants
- Exposure
- Triglyceride-glucose (TyG) control-level classes 2–4 vs class 1; cumulative TyG
- Outcome
- Incidence of stroke
- Follow-up
- 3-year follow-up
Methodological detailsnationwide
- Nationwide
Main finding
As reported in the abstract
Incident stroke by TyG control class
Each group vs class 1Odds ratio (95% CI)P value
Class 2
1.39(1.003–1.92)
P = 0.046Class 3
1.28(0.92–1.77)
P = 0.147Class 4
1.28(0.84–1.94)
P = 0.238- Elevated cumulative of TyG (cumTyG) associated with increased incidence of stroke
- OR 1.13 (95% CI 1.05, 1.22, P = 0.002)
Observational data: associations, not effects.
Original publication
Association between cumulative changes of the triglyceride glucose index and incidence of stroke in a population with cardiovascular-kidney-metabolic syndrome stage 0–3: a nationwide prospective cohort study. Cardiovasc Diabetol. Published 12 May 2025. doi:10.
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