Association between changes in glycosylated hemoglobin during the second and third trimesters and adverse pregnancy outcomes among women without hyperglycemia in pregnancy
Authors' conclusion
Among pregnant women without HIP, elevated HbA1c levels in the second or third trimester are associated with increased risks of adverse pregnancy outcomes.
Study context
- Population
- Pregnant women without hyperglycemia in pregnancy who had serum HbA1c and delivered at Women's Hospital, Zhejiang University School of Medicine, May 2022–March 20234 groups
- Participants
- 1,057 women
- Exposure
- HbA1c change categories in second and third trimesters
- Outcome
- Hypertensive disorders of pregnancy (HDP)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Adjusted odds ratio (95% CI)
HbA1c_S<5.5 %, HbA1c_T≥6.1 %
2.72(1.24–5.97)
HbA1c_S≥5.5 %, HbA1c_T<6.1 %
2.59(1.15–5.84)
Observational data: associations, not effects.
Further findings
Per 1% increase in HbA1c difference between second and third trimesters
- Risk of hypertensive disorders of pregnancy (HDP) increased about 1.96 times
- Risk of large-for-gestational-age baby increased about 1.30 times
HbA1c trend
- Upward trend in HbA1c from second to third trimester among women without hyperglycemia in pregnancy (HIP)
Original publication
Association between changes in glycosylated hemoglobin during the second and third trimesters and adverse pregnancy outcomes among women without hyperglycemia in pregnancy. Diabetes Res Clin Pract. Published 28 August 2024. doi:10.
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