Association between atherogenic index of plasma and new-onset stroke in a population with cardiovascular-kidney-metabolic syndrome stages 0–3: insights from CHARLS
Authors' conclusion
This study provides evidence that baseline AIP levels were significantly positively associated with the risk of stroke in individuals with CKM syndrome stages 0-3, and AIP may serve as an effective risk marker for early identification of high-risk individuals prone to stroke within the CKM stages syndrome 0-3 population.
Study context
- Population
- Participants with Cardiovascular-Kidney-Metabolic (CKM) syndrome stages 0–3 from the China Health and Retirement Longitudinal Study (CHARLS)
- Participants
- 7,754 participants
- Exposure
- Atherogenic index of plasma (AIP) quartiles Q2, Q3, Q4 vs Q1
- Outcome
- Incidence of new-onset stroke
- Follow-up
- Median 6.8 years
Main finding
As reported in the abstract
New-onset stroke
Each group vs Q1Hazard ratio (95% CI)
Q2
1.352(1.009–1.811)
Q3
1.421(1.064–1.897)
Q4
1.414(1.052–1.900)
- First stroke events, whole cohort
- 455 participants (5.9%)
Observational data: associations, not effects.
Further findings
Shape of AIP–stroke association (restricted cubic spline)
- Nonlinear association; P-overall
- < 0.05
- P-non-linear
- < 0.05
- Inflection point of AIP
- 0.32
Original publication
Association between atherogenic index of plasma and new-onset stroke in a population with cardiovascular-kidney-metabolic syndrome stages 0–3: insights from CHARLS. Cardiovasc Diabetol. Published 16 April 2025. doi:10.
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