Association between arterial stiffness/remodeling and new-onset type 2 diabetes mellitus in general population
Authors' conclusion
Elevated arterial stiffness is independently associated with incident type 2 diabetes. For most arterial stiffness markers, the associations with incident type 2 diabetes were more robust in individuals with a higher GRS for diabetes.
Study context
- Population
- General population, Rotterdam Study; mean age 67.2 years
- Participants
- 3,055 participants
- Exposure
- Higher vs lower arterial stiffness/remodeling markers
- Outcome
- Incident T2D
- Follow-up
- Median 14.0 years
Methodological detailsMendelian randomization analysis, genetic risk score (403 SNPs)
- Mendelian randomization analysis
- Genetic risk score (403 SNPs)
Main finding
As reported in the abstract
Incident T2D per higher arterial stiffness/remodeling marker
Carotid-femoral pulse wave velocity: HR
1.18 (1.04-1.35) (95% CI)
Carotid distensibility coefficient: HR
1.17 (1.04-1.32) (95% CI)
Carotid intima-media thickness: HR
1.15 (1.01-1.32) (95% CI)
Observational data: associations, not effects.
Further findings
Effect modification by genetic risk score (GRS) for T2D
- Associations stronger among individuals with higher GRS for T2D
Causality (Mendelian randomization (MR) analysis)
- MR analysis did not support causality of the observed associations
Original publication
Association between arterial stiffness/remodeling and new-onset type 2 diabetes mellitus in general population. Diabetes Res Clin Pract. Published 5 January 2023. doi:10.
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