Assessment of testicular function in boys with hematological malignancies: a prospective longitudinal study
Authors' conclusion
Testicular dysfunction associated with pediatric hematologic malignancies is mostly reversible. However, delayed Sertoli cell maturation and persistent compensated Leydig cell insufficiency indicate residual testicular vulnerability
Study context
- Population
- Boys and adolescents with acute lymphoblastic leukemia, acute myeloid leukemia or non-Hodgkin lymphoma treated at a tertiary pediatric center in Argentina, 2013–2019
- Participants
- 63 participants
- Outcome
- Testicular function (Sertoli and Leydig cell hormonal markers) from diagnosis to 3 years after treatment
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Prepubertal boys: Sertoli cell function mildly impaired at diagnosis, with reduced AMH and FSH
- Prepubertal boys: AMH increased during induction chemotherapy, fluctuated during treatment, normalized thereafter and remained stable up to 3 years post-treatment
- Transient FSH suppression coincided with high-dose corticosteroid exposure
- Boys entering puberty during follow-up: persistently elevated AMH relative to pubertal stage, suggesting delayed Sertoli cell maturation
- Pubertal patients: transient seminiferous tubular dysfunction (increased FSH, decreased inhibin B), recovered by 3 years after treatment
- Mild compensated Leydig cell dysfunction persisted: elevated LH despite normal testosterone
Observational data: associations, not effects.
Original publication
Assessment of testicular function in boys with hematological malignancies: a prospective longitudinal study. J Clin Endocrinol Metab. Published 3 September 2026. doi:10.
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