Andrological Outcomes in Boys Undergoing Testicular Tissue Extraction Prior to Gonadotoxic Treatment: Evolution During Peripuberty and Young Adulthood
Authors' conclusion
Males undergoing TTE prior to gonadotoxic therapy frequently develop persistent Sertoli cell dysfunction, with limited fertility potential in many cases. These findings underscore the importance of systematic, long-term andrological surveillance and personalised fertility counselling in this high-risk population.
Study context
- Population
- Males who underwent testicular tissue extraction (TTE) with cryopreservation prior to gonadotoxic therapy, treated 2009–2022 at Lille University Hospital (median age at TTE 5.6 years; median age at last follow-up 14.6 years); malignant haematological disorders 52%, non-malignant diseases 34%, solid tumours 14%; 80% allogeneic haematopoietic stem cell transplantation
- Participants
- 50 males
- Outcome
- Long-term endocrine and exocrine testicular function (LH, FSH, testosterone, inhibin B, AMH; semen analysis)
- Follow-up
- Puberty onset to young adulthood
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Testicular function at Tanner stage 5
- Spontaneous pubertal onset
- All participants
- Elevated LH
- 18%
- Elevated FSH
- 75%
- Low inhibin B
- 89%
Observational data: associations, not effects.
Further findings
Stratified analyses
- Radiotherapy associated with higher gonadotropin levels at equivalent chemotherapy doses
- Sertoli cell impairment more pronounced in malignant disease and peri-pubertal treatment
Post-pubertal semen analysis
- Spermatozoa detected among 12 semen analyses, all in non-malignant cases without radiotherapy
- 42%
Original publication
Andrological Outcomes in Boys Undergoing Testicular Tissue Extraction Prior to Gonadotoxic Treatment: Evolution During Peripuberty and Young Adulthood. Clin Endocrinol (Oxf). Published 14 January 2026. doi:10.
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