Assessment of Glycemia Risk Index and Standard Continuous Glucose Monitoring Metrics in a Real-World Setting of Exercise in Adults With Type 1 Diabetes: A Post-Hoc Analysis of the Type 1 Diabetes and Exercise Initiative
Primary result · GRIResult — go to the resultAbsolute mean difference −1.70 CI −2.73 to −0.67Authors' conclusion
Glycemia Risk Index improved on exercise versus sedentary days, despite increased TBR, which is weighted most heavily in the GRI calculation, due to a robust reduction in TAR.
Study context
- Population
- Adults (≥18 years) with T1D in the T1D EXercise Initiative study wearing continuous glucose monitoring (CGM) and activity trackers for four weeks, with >70% CGM and activity data408 adults
- Participants
- 3,790 vs 1,865
- Comparison
- Exercise days vs sedentary days
- Exercise daysn = 3,790
- Sedentary daysn = 1,865reference
- Primary endpoint
- Glycemia Risk Index (GRI)
- Follow-up
- Within 24 hours postexercise
Methodological detailspost-hoc analysis, linear mixed-effects regression
- Post-hoc analysis
- Linear mixed-effects regression
Primary result
GRI
Absolute mean difference
−1.70
CI −2.73 to −0.67
P < 0.001
By group
Exercise days
29.9
mean · SD 24.0
Sedentary days
34.0
mean · SD 26.1
Exercise daysvs Sedentary days
absolute mean difference −1.70 (CI −2.73 to −0.67); P < 0.001
As reported in the abstract
- Reduction in glycemic risk
- ≈5%
Further findings
| Outcome | Estimate | P value | |
|---|---|---|---|
| Percent TIR (70-180 mg/dL) · within 24 hours postexerciseIncreased on exercise days | absolute mean difference 2.67 (CI 1.83–3.50) | P < 0.001 | |
| TBR · within 24 hours postexerciseIncreased on exercise days | relative mean difference 1.17 (CI 1.12–1.22) | P < 0.001 | |
| TAR · within 24 hours postexerciseDecreased on exercise days | relative mean difference 0.84 (CI 0.79–0.88) | P < 0.001 | |
| −2024Difference (linear scale) |
Original publication
Assessment of Glycemia Risk Index and Standard Continuous Glucose Monitoring Metrics in a Real-World Setting of Exercise in Adults With Type 1 Diabetes: A Post-Hoc Analysis of the Type 1 Diabetes and Exercise Initiative. J Diabetes Sci Technol. Published 17 April 2024. doi:10.
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