Assessing the stress hyperglycemia ratio in hyperlipidemia patients to predict all-cause mortality: A retrospective cohort study
Authors' conclusion
In the study of first-admission hyperlipidemia patients, elevated SHR levels were significantly associated with in-hospital, ICU, and 28-day all-cause mortality. Incorporating SHR into existing models enhances their predictive ability, holding significant clinical value for identifying high-risk patients.
Study context
- Population
- First-admission hyperlipidemia patients aged 18–100 years, Medical Information Mart for Intensive Care IV (MIMIC-IV); mean age 70 ± 12.1, 36.0% female
- Participants
- 4,883 patients
- Exposure
- Stress Hyperglycemia Ratio (SHR) and all-cause mortality
- Outcome
- In-hospital, ICU and 28-day all-cause mortality
Methodological detailsMIMIC-IV database, SHR quartiles, Cox regression, restricted cubic spline, machine learning models
- MIMIC-IV database
- SHR quartiles
- Cox regression
- Restricted cubic spline
- Machine learning models
Main finding
As reported in the abstract
All-cause mortality by SHR
ICU mortality, HR
1.29 (1.08-1.56) (95% CI)
In-hospital mortality, HR
1.24 (1.07-1.44) (95% CI)
28-day mortality, HR
1.32 (1.15-1.52) (95% CI)
Observational data: associations, not effects.
Further findings
- Adding SHR to general models improved predictive accuracy
Original publication
Assessing the stress hyperglycemia ratio in hyperlipidemia patients to predict all-cause mortality: A retrospective cohort study. Diabetes Res Clin Pract. Published 31 May 2025. doi:10.
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