Assessing Risk Classification in Medication-Induced Diabetes during Induction Therapy in Pediatric Acute Lymphoblastic Leukemia
Authors' conclusion
Older age, higher body mass index, greater central nervous system status, Trisomy 21, and prednisone steroid type were risk factors associated with MID in our cohort. HR patients developed significantly more complications than SR patients including MID and infection.
Study context
- Population
- Pediatric patients diagnosed with acute lymphoblastic leukemia during induction therapy, IWK Health, Halifax, Nova Scotia, Canada, 2000–2019142 males · 120 females
- Participants
- 262 patients
- Exposure
- High-risk vs standard-risk regimens
- Outcome
- Incidence of and risk factors for medication-induced diabetes (MID) during induction
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Risk factors for MID · induction
- Older age, higher BMI, greater central nervous system status, Trisomy 21 and prednisone steroid type were risk factors associated with medication-induced diabetes (MID)
Observational data: associations, not effects.
Safety
Complications including MID and infection · induction
- HR patients developed significantly more complications than standard-risk (SR) patients, including MID and infection
Original publication
Assessing Risk Classification in Medication-Induced Diabetes during Induction Therapy in Pediatric Acute Lymphoblastic Leukemia. Pediatr Diabetes. Published 16 December 2023. doi:10.
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