Antigen specific T cells in people with obesity at five months following ChAdOx1 COVID-19 vaccination
Authors' conclusion
These data indicate that PWO who have completed a primary course of ChAdOx1 COVID-19 vaccination have robust, durable, and functional antigen specific T cell immunity that is comparable to that seen in people without obesity.
Study context
- Population
- Subjects 5 months after a two-dose primary course of ChAdOx1 nCoV-19 (AZD1222) vaccination
- Participants
- 50 subjects
- Exposure
- People with obesity vs matched controls
- People with obesity (PWO)n = 30
- Controlsn = 20reference
- Outcome
- SARS-CoV-2 spike-specific T cells (CD4+, CD8+; IFNγ, TNFα) by multicolour flow cytometry
- Follow-up
- 5 months after vaccination
Methodological detailsmatched controls
- Matched controls
Main finding
As reported in the abstract
- Circulating SARS-CoV-2-specific T cells readily detected across the cohort, with robust responses to spike peptide stimulation in both T cell lines
- PWO and controls had comparable levels of CD4+ and CD8+ spike-specific T cells
- Polyfunctional T cells detected at similar frequencies in PWO and controls
Observational data: associations, not effects.
Original publication
Antigen specific T cells in people with obesity at five months following ChAdOx1 COVID-19 vaccination. Int J Obes (Lond). Published 8 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →