Analysis of Serum Free Thyroxine Concentrations in Healthy Term Neonates Underlines Need for Local and Laboratory-Specific Reference Interval: A Systematic Review and Meta-Analysis of Individual Participant Data
Authors' conclusion
We conclude that our attempts at normalizing fT4 assay results were unsuccessful.
Study context
- Population
- Healthy term newborns aged 2–27 days, born to mothers without thyroid disease in iodine-sufficient regions13 assays
- Participants
- 4,206 newborns20 studies
- Outcome
- Uniform age-specific neonatal fT4 reference intervals usable for every assay
Methodological detailsMEDLINE and Embase searched (search date December 6, 2023); authors invited to supply data
- MEDLINE and Embase searched (search date December 6, 2023); authors invited to supply data
Pooled result
As reported in the abstract
Normalization of fT4 across studies
- Normalization by assay-specific adult RI mean and SD (Z-scores): significant difference in free thyroxine (fT4) across studies (LMM)
- p < 0.001
- Normalization to Cobas values via method/assay comparison: significant differences between normalized data
- LMM p < 0.001
Original publication
Analysis of Serum Free Thyroxine Concentrations in Healthy Term Neonates Underlines Need for Local and Laboratory-Specific Reference Interval: A Systematic Review and Meta-Analysis of Individual Participant Data. Thyroid. Published 2 April 2024. doi:10.
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