An Exploratory Analysis of Continuous Glucose Monitoring Metrics in Relation to Prediabetes in Youths with Obesity
Authors' conclusion
This exploratory study showed that TITR measured in free-living may aid the identification of PD in youths with obesity, although the discriminative ability of CGM metrics was limited. Future works will focus on the analysis of the concordance of plasma glucose and CGM during OGTT, as well as their predictive performance.
Study context
- Population
- Youths with obesity (BMI-for-age > 2SD, age 10–18 years) wearing a Freestyle Libre 2 continuous glucose monitoring (CGM) sensor for 2 weeks; age 12.6 ± 1.9 years, 42.4% female, BMI 32.8 ± 6.6 kg/m², HbA1c 5.4 ± 0.2%
- Participants
- 84 participants
- Exposure
- CGM metrics in prediabetes (PD) vs normal glucose tolerance (NGT) youths with obesity
- Outcome
- Relation of CGM metrics, incl. time in tight ranges (TITR) 70-140 and 70-120 mg/dL, to PD
Methodological detailsexploratory
- Exploratory
Main finding
As reported in the abstract
CGM metrics: TITR 70-140 and 70-120 mg/dL
- Both time in tight ranges (TITR) 70-140 and 70-120 mg/dL significantly predict PD, independent of age and sex, with modest discriminative ability
- P = 0.02
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| HbA1c, blood glucose at baseline, 30, 90 and 120 min, and glucose AUC after glucose loadHigher in PD | P < 0.05 |
Original publication
An Exploratory Analysis of Continuous Glucose Monitoring Metrics in Relation to Prediabetes in Youths with Obesity. Diabetes Technol Ther. Published 22 December 2025. doi:10.
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