Altered Intrinsic Brain Activity Related to Neurologic and Motor Dysfunction in Diabetic Peripheral Neuropathy Patients
An erratum to this article was published (J Clin Endocrinol Metab, 10 Mar 2023 ↗)
Authors' conclusion
Patients with DPN have abnormal brain activity in sensorimotor and cognitive brain areas, which may implicate the underlying neurophysiological mechanisms in intrinsic brain activity.
Study context
- Population
- Patients with T2D with or without DPN, and healthy controls
- Participants
- 28 / 43 / 32
- Exposure
- DPN vs NDPN vs healthy controls (HCs)
- DPNn = 28
- NDPNn = 43
- HCsn = 32reference
- Outcome
- Intrinsic resting brain activity (ALFF, fALFF, regional homogeneity (ReHo))
Methodological detailsresting-state functional MRI
- Resting-state functional MRI
Main finding
As reported in the abstract
- DPN vs NDPN: decreased amplitude of low-frequency fluctuation (ALFF) in right orbital superior frontal gyrus (ORBsup) and medial superior frontal gyrus (SFGmed), increased ALFF in left inferior temporal gyrus (ITG), decreased fractional ALFF (fALFF) in right SFGmed
- NDPN vs HCs: increased ALFF in right ORBsup, middle frontal gyrus and left orbital middle frontal gyrus; decreased fALFF in right middle temporal gyrus
- Mean ALFF of right ORBsup negatively correlated with Toronto Clinical Scoring System scores and gait speed in diabetics
- Mean ALFF/fALFF of right SFGmed and mean ALFF of left ITG and right ORBsup differentiated DPN from NDPN in ROC analysis
Observational data: associations, not effects.
Original publication
Altered Intrinsic Brain Activity Related to Neurologic and Motor Dysfunction in Diabetic Peripheral Neuropathy Patients. J Clin Endocrinol Metab. Published 5 November 2022. doi:10.
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