Allometric versus traditional body-shape indices and risk of colorectal cancer: a Mendelian randomization analysis
Authors' conclusion
This large MR study provides strong evidence for a potential causal positive association of the allometric indices ABSI and WHI with CRC in both sexes, thus establishing the association between abdominal fat and CRC without the limitations of the traditional waist size indices and independently of BMI. Among the BMI-adjusted traditional indices, WHR and HC provided equivalent associations with WHI and HI, while differences were observed between WC and ABSI.
Study context
- Population
- Genetic data from UK Biobank and GIANT consortium (exposures) and GECCO, CORECT and CCFR consortia (colorectal cancer (CRC))
- Comparison
- Genetically predicted allometric body-shape indices (A Body Shape Index (ABSI), Hip Index (HI), Waist-to-Hip Index (WHI)) vs Body Mass Index (BMI)-adjusted traditional indices (Waist Circumference (WC), Hip Circumference (HC), Waist-to-Hip Ratio (WHR)) and BMI
- Outcome
- CRC risk (colon and rectal cancer), by sex
Methodological detailstwo-sample Mendelian randomization (MR), cancer site- and sex-specific, Data from UK Biobank, GIANT, GECCO, CORECT and CCFR consortia
- Two-sample MR
- Cancer site- and sex-specific
- Data from UK Biobank, GIANT, GECCO, CORECT and CCFR consortia
Main finding
As reported in the abstract
CRC risk per SD of genetically predicted index
- WHI and CRC, men: OR per SD
- 1.20 (1.03-1.39) (95% CI)
- WHI and CRC, women: OR per SD
- 1.15 (1.06-1.24) (95% CI)
- ABSI and colon cancer, men: OR
- 1.27 (1.03-1.57) (95% CI)
- ABSI and rectal cancer, men: OR
- 1.40 (1.10-1.77) (95% CI)
- ABSI and colon cancer, women: OR
- 1.20 (1.07-1.35) (95% CI)
Further findings
BMI-adjusted traditional indices
- BMI-adjusted WHR and HC showed similar associations to WHI and HI; WC similar to ABSI only in women
Original publication
Allometric versus traditional body-shape indices and risk of colorectal cancer: a Mendelian randomization analysis. Int J Obes (Lond). Published 31 January 2024. doi:10.
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