All-Cause Mortality and Health Care Resource Utilization in Patients with Type 1 Diabetes Treated with Glucagon-like Peptide 1 Receptor Agonists/Glucose-Dependent Insulinotropic Polypeptide
Authors' conclusion
These findings suggest that use of GLP-1 RA/GIP analogs in patients with T1D was associated with significantly lower HCRU, including hospitalizations and ED visits, and reduced all-cause mortality. Further studies are warranted to confirm these observational findings.
Study context
- Population
- Patients with T1D identified by ICD-10 codes, excluding T2D or SGLT2i use; predominantly white and femalematched cohort
- Participants
- 4,212 vs 4,212
- Exposure
- GLP-1 RA or GLP-1 RA/GIP dual agonist vs no GLP-1 single/dual receptor agonist
- Comparisonn = 4,212
- Controln = 4,212reference
- Outcome
- All-cause mortality, health care resource utilization (HCRU), endoscopic procedures and use of gastrointestinal prescriptions
- Follow-up
- 2 years
Methodological detailsTriNetX database, 1:1 propensity-score matched
- TriNetX database
- 1:1 propensity-score matched
Main finding
As reported in the abstract
Primary outcomes
Each group vs controlEstimate (95% CI)P value
Comparison
HR (all-cause mortality) 0.18(0.11–0.30)
P < 0.0001Comparison
OR (all-cause hospitalizations) 0.30(0.20–0.45)
P < 0.0001Comparison
OR (ED visits) 0.56(0.43–0.71)
P < 0.0001Comparison
OR (endoscopy use) 0.52(0.38–0.70)
P < 0.0001Comparison
OR (laxative prescription) 0.52(0.43–0.63)
P < 0.0001Comparison
OR (prokinetic prescription) 0.74(0.57–0.96)
P = 0.0238Observational data: associations, not effects.
Safety
| Outcome | P value |
|---|---|
| DKA and hypoglycaemiaComparison vs Control · DKA: no significant difference | P = 0.1030 |
| DKA and hypoglycaemiaComparison vs Control · hypoglycemia: no significant difference | P = 0.7474 |
Original publication
All-Cause Mortality and Health Care Resource Utilization in Patients with Type 1 Diabetes Treated with Glucagon-like Peptide 1 Receptor Agonists/Glucose-Dependent Insulinotropic Polypeptide. Diabetes Technol Ther. Published 1 January 2026. doi:10.
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