Refracture and mortality risk in the elderly with osteoporotic fractures: the AGES-Reykjavik study
Authors' conclusion
The risk of refracture significantly increases in the first six years following the initial fracture.
Study context
- Population
- Icelandic elderly aged 65 years and older, AGES-Reykjavik cohort
- Participants
- 4,778 elderly
- Outcome
- Progression of fractures to refractures and mortality
Methodological detailsobservational, multi-state models
- Observational
- Multi-state models
Main finding
As reported in the abstract
Refracture risk
- Elderly men, and elderly women above 80 years, had a distinct imminent refracture risk lasting 2-6 years, followed by a sharp decline
- Elderly women below 75 maintained a nearly constant refracture risk profile for ten years
Observational data: associations, not effects.
Further findings
5-year mortality burden after hip fracture, elderly men and women regardless of age
- Hip fractures (highest 5-year mortality burden)
- 30-63%
5-year mortality burden after vertebral fracture, elderly men and women regardless of age
- Vertebral fractures (highest 5-year mortality burden)
- 24-55%
Mortality after lower leg fractures, elderly men over 80
- Lower leg fractures also posed a significant mortality risk
Original publication
Refracture and mortality risk in the elderly with osteoporotic fractures: the AGES-Reykjavik study. Osteoporos Int. Published 24 April 2024. doi:10.
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