Age and Gender Adjusted Free T3 (FT3) Levels as Novel Predictors of Survival
Authors' conclusion
Low FT3 AGAPs predicted poor survival, most strongly among not healthy people.
Study context
- Population
- Patients with thyroid function tests 2008–2014 crossed with electronic health records, excluding those taking thyroid preparations or anti-thyroid drugs; subgroups not healthy (≥1 of 5 chronic conditions) and healthysets of tests
- Participants
- 258,695 patients
- Exposure
- Lowest 5 vs highest 50 percentiles of initial FT3 and gender-adjusted percentiles (AGAPs)
- Outcome
- HR for death
- Follow-up
- Median 6.8 years
Methodological detailsbig-data, age- and gender-adjusted percentiles (AGAPs)
- Big-data
- Age- and gender-adjusted percentiles (AGAPs)
Main finding
As reported in the abstract
Death by initial FT3 AGAPs, lowest 5 vs highest 50 percentiles
Lowest 5 percentiles vs Highest 50 percentilesHR for death (CI)P value
Not healthy
5.71(5.23–6.26)
P < 0.001Healthy
3.92(3.06–5.02)
P < 0.001- Died, not healthy
- 5865/151 868 (10.4%)
- Died, healthy
- 2504/106 827 (2.3%)
Observational data: associations, not effects.
Further findings
Deaths · median 6.8 years
- Deaths: not healthy n = 151 868; healthy n = 106 827
Original publication
Age and Gender Adjusted FT3 Levels as Novel Predictors of Survival. J Clin Endocrinol Metab. Published 7 June 2023. doi:10.
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