Adverse cardiometabolic profile of women 6 months and 2 years after gestational hypertension
Authors' conclusion
Evidence of cardiometabolic dysfunction, including obesity, percent fat mass, dyslipidaemia and markers of insulin resistance, was present at 6 months after GH. By 2 years postpartum, over one-third of these women meet metabolic syndrome criteria. Further studies are required to characterise targets for early postpartum intervention to mitigate future cardiometabolic health outcomes.
Study context
- Population
- Postpartum women assessed 6 months and 2 years after gestational hypertension (GH) or normotensive pregnancy
- Comparison
- Women after gestational hypertension vs after normotensive pregnancy
- Normotensive pregnancyn = 118reference
- Primary endpoint
- Body composition and cardiometabolic parameters
- Follow-up
- 6 months and 2 years postpartum
Methodological detailssub-study of the Postpartum Physiology, Psychology and Paediatric cohort study
- Sub-study of the Postpartum Physiology, Psychology and Paediatric cohort study
Primary result
As reported in the abstract
Percent fat mass · 6 months
P < 0.001
Further findings
| Outcome | GH | P value |
|---|---|---|
| Weight · 6 monthsGH vs Controls | 81.4 kg | P < 0.001 |
| Obesity rates · 6 monthsGH vs Controls | 52% | P < 0.001 |
| HOMA-IR · 6 monthsGH vs Controls | 1.94 (interval 1.22–3.80) | P < 0.001 |
| LDL-C · 2 years postpartumGH vs Controls | 2.7 (interval 2.4–3.2) mmol/L | P = 0.04, q = 0.07 |
| Metabolic syndrome rates · 2 years postpartumGH vs Controls | 36% | P = 0.001 |
- Weight: Controls 63.5 kg
- Obesity rates: Controls 18%
- HOMA-IR: Controls 0.97 (interval 0.62–1.43)
- LDL-C: Controls 2.3 (interval 1.9–2.8) mmol/L
- Metabolic syndrome rates: Controls 4%
Other parameters · 6 months
- GH: lower breastfeeding rates, markedly higher systolic and diastolic BP, lower HDL-C, higher TG and insulin vs controls
LDL-C · 2 years postpartum
- Metabolic differences persisted at 2 years postpartum
Change over time
- Percent fat mass, waist-to-hip ratio and total cholesterol improved for all women over time
Original publication
Adverse cardiometabolic profile of women 6 months and 2 years after gestational hypertension. Diabetes Obes Metab. Published 3 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →