ADRB3, LEPR, FTO and PPARG variants contribute to obesity-related metabolic syndrome in Brazilian adults: a polygenic risk score approach
Authors' conclusion
Variants in ADRB3, LEPR, FTO and PPARG play an important role in adiposity related to MetS, contributing to metabolic disturbances and pro-inflammatory state that increase cardiovascular risk in adult subjects. The integration of these variants into a polygenic risk score highlights a cumulative genetic susceptibility, as reflected by higher scores in MetS and a clear gradient across the number of MetS components.
Study context
- Population
- Brazilian adults
- Participants
- 420 adults
- Comparison
- Metabolic syndrome (MetS) vs without MetS
- MetSn = 179
- Without MetSn = 241reference
- Outcome
- Association of variants with risk of MetS
Methodological detailsselected from a Brazilian adult cohort, polygenic risk score
- Selected from a Brazilian adult cohort
- Polygenic risk score
Main finding
As reported in the abstract
Odds ratio (95% CI)P value
ADRB3 rs4994A>G
3.71(1.71–8.03)
P = 0.001LEPR rs1137100A>G
2.52(1.33–4.79)
P = 0.005Observational data: associations, not effects.
Further findings
Prediction of anthropometric, metabolic and inflammatory alterations related to MetS
- ADRB3 rs4994A>G, LEPR rs1137100A>G, FTO rs17817449T>G and PPARG rs1801282C>G predicted MetS-related alterations
- P < 0.05
Polygenic risk score (nPRS)
- ROC discrimination of MetS (limited sensitivity), AUC
- 0.616, p < 0.001
- Increasing nPRS associated with higher number of MetS components
- P < 0.001
- nPRS higher in subjects with MetS
Original publication
ADRB3, LEPR, FTO and PPARG variants contribute to obesity-related metabolic syndrome in Brazilian adults: a polygenic risk score approach. Int J Obes (Lond). Published 21 September 2026. doi:10.
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